Excess Weight and Insulin Increase Prostate Cancer Mortality

Multiple studies have indicated that obesity before or at the time of prostate cancer diagnosis increases the mortality risk. However, they have not attempted to explain the association, the authors said.

Among obesity-driven metabolic changes that could influence prostate cancer mortality, hyperinsulinemia stands out as a prime suspect, they continued.

Laboratory studies demonstrated that mice fed a high-energy diet gained weight, became hyperinsulinemic, had accelerated growth of prostate cancer xenografts, and had increased downstream signaling of the insulin receptor in neoplastic prostate tissue.

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